Article
Potency of an oxidation-resistant mutant of secretory leukocyte proteinase inhibitor in lipopolysaccharide-induced emphysema in hamsters.
Pulmonary pharmacology - 1 Mar 1993
Stolk J, Heinzel-Wieland R, Saunders D, Dijkman J H, Steffens G
Abstract excerpt
Secretory leukocyte inhibitor (SLPI) is a potent inhibitor of serine proteinases, but sensitive to oxidative inactivation due to a methionine residue in the active centre of the inhibitor. We compared the potency of an oxidation-resistant mutant of recombinant SLPI with native recombinant SLPI in...
Topics
- Animals
- Chemotaxis, Leukocyte
- Cricetinae
- Emphysema
- In Vitro Techniques
- Lipopolysaccharides
- Mesocricetus
- Mutation
- Neutrophils
- Oxidation-Reduction
- Proteinase Inhibitory Proteins, Secretory
- Proteins
- Reactive Oxygen Species
- Recombinant Proteins
- Serine Proteinase Inhibitors