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Article

Alpha 1-antitrypsin variants produced by recombinant DNA: differences in elastase inhibitory activity and resistance to oxidant agents.

International journal of tissue reactions - 1 Jan 1990

Luisetti M, Pozzi E, Diomede L, Donnini M, Piccioni P D, Bolzoni G, Peona V, Salmona M

Abstract excerpt

Inherited or "acquired" deficiency of alpha 1-antitrypsin (believed to be the cause of pulmonary emphysema) will probably be treated in the future by replacement with alpha 1-antitrypsin purified from human plasma or produced by recombinant DNA, which seems promising because it permits site-specific mutagenesis in the oxidizable active site of the normal human alpha 1-antitrypsin. The aim of this in-vitro study...

Topics

Animals
Chloramines
DNA, Recombinant
Drug Resistance
Genetic Variation
Hydrogen Peroxide
Oxidation-Reduction
Pancreatic Elastase
Xanthine Oxidase
alpha 1-Antitrypsin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2102901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2102901-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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