Article
Oncogenesis by mutations in anti-oncogenes: a view.
Anticancer research - 1 Jan 2000
Den Otter W, Koten J W, Van der Vegt B J, Beemer F A, Boxma O J, Derkinderen D J, De Graaf P W, Huber J, Lips C J, Roholl P J
Abstract excerpt
Oncogenesis is the result of accumulation of specific gene mutations. Two classes of specific cancer mutations are distinguished: namely those affecting anti-oncogenes and those in which oncogenes are involved. Anti-oncogenes are thought to regulate normal growth by encoding proteins that inhibit the expression of the oncogenes. This is in line with the observation that tumor cells are often homozygous for a...
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