Article
Incorporating pathologists' criteria of malignancy into the evolutionary model for cancer development.
Journal of cellular biochemistry - 1 Sept 2004
Fischer Andrew H, Young Kyle A, DeLellis Ronald A
Abstract excerpt
A wide variety of alterations in cell and tissue structure still form the basis for cancer diagnosis by pathologists. Cancer development is recognized to be an evolutionary process [Foulds, 1954; Cairns, 1975; Nowell, 1976; Sager, 1982; Tomlinson et al., 1996; Cahill et al., 1999; Tomlinson and Bodmer, 1999], but the phenotypic changes diagnostic of cancer (pathologists' "criteria of malignancy") have not been...
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