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Article

A general model of carcinogenesis (I)--Tumor evolution and gene deletion.

Medical hypotheses - 1 Apr 1993

Chigira M

Abstract excerpt

Carcinogenesis is functionally a deletion alteration rather than addition of genetic information. Repressor genes may be more sensitive to 'neutral' mutations of DNA than those of structural genes, since selection pressure for deletion of repressors is extremely low in multicellular organisms. Dysfunction of repressors caused by genomic mutation induces autonomic expression of structural genes which is programmed...

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Identifiers

PMID: 8321157
DOI: 10.1016/0306-9877(93)90045-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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