A general model of carcinogenesis (I)--Tumor evolution and gene deletion.

doi:10.1016/0306-9877(93)90045-r

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Article

A general model of carcinogenesis (I)--Tumor evolution and gene deletion.

Medical hypotheses - 1 Apr 1993

Chigira M

Abstract excerpt

Carcinogenesis is functionally a deletion alteration rather than addition of genetic information. Repressor genes may be more sensitive to 'neutral' mutations of DNA than those of structural genes, since selection pressure for deletion of repressors is extremely low in multicellular organisms. Dy...

Topics

Animals
DNA Repair
Gene Deletion
Genes, Tumor Suppressor
Humans
Models, Genetic
Mutation
Neoplasms

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