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Article

The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity.

Journal of lipid research - 1 Jun 1998

Dong L M, Innerarity T L, Arnold K S, Newhouse Y M, Weisgraber K H

Abstract excerpt

Both apolipoprotein (apo) E2 and apoE-Leiden (tandem repeat of amino acids 121-127) are associated with type III hyperlipoproteinemia and bind defectively to low density lipoprotein receptors. Removing the carboxyl terminus of both variants (residues 192-299) increases receptor-binding activity,...

Topics

Apolipoprotein E2
Apolipoprotein E3
Apolipoproteins E
Binding Sites
Binding, Competitive
Dimyristoylphosphatidylcholine
Genetic Variation
Humans
Kinetics
Models, Molecular
Protein Structure, Secondary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, LDL

Recombinant Fusion Proteins

Source

Identifiers

PMID: 9643348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9643348-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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