Article
Rare HRAS1 alleles are a risk factor for the development of brain tumors.
Cancer - 1 Dec 2001
Vega A, Sobrido M J, Ruiz-Ponte C, Barros F, Carracedo A
Abstract excerpt
BACKGROUND: The highly polymorphic HRAS1 minisatellite locus, located 1 kilobase downstream from the H-ras1 gene, has been associated with increased susceptibility to a variety of cancers. Microsatellite instability (MI), another molecular abnormality observed in human neoplasms, most likely reflects an increased mutation rate and also is thought to underlie cancer predisposition. The purpose of this study was to...
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