Article
Analysis of peptide-binding motifs for two disease associated HLA-DR13 alleles using an M13 phage display library.
Immunology - 1 Aug 1996
Davenport M P, Quinn C L, Valsasnini P, Sinigaglia F, Hill A V, Bell J I
Abstract excerpt
Major histocompatibility complex (MHC) molecules bind peptides bearing an appropriate 'sequence motif' for MHC binding. The use of phage display libraries exploits the ability of MHC class II molecules to exchange peptides in solution and thus select out peptide sequences with high-affinity bindi...
Topics
- Alleles
- Amino Acid Sequence
- Bacteriophage M13
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Hepatitis B
- Humans
- Malaria
- Molecular Sequence Data
- Peptides