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Article

X-ray structures of two single-residue mutants of DNase I: H134Q and Y76A.

Protein engineering - 1 Jun 1993

Weston S, Suck D

Abstract excerpt

The structures of the single-residue mutants H134Q and Y76A of bovine pancreatic DNase I have been determined and refined including data to 2.3 and 2.4 A resolution respectively, by X-ray crystallography. H134 is an essential catalytic residue, while Y76 contributes to the binding of DNA by providing a large van der Waals contact area that stabilizes the wide minor groove seen in DNase I-DNA complexes. The mutant...

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PMID: 8332591
DOI: 10.1093/protein/6.4.349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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