Article
In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core.
Journal of molecular biology - 5 Sept 1991
Stites W E, Gittis A G, Lattman E E, Shortle D
Abstract excerpt
The crystal structure of the staphylococcal nuclease mutant V66K, in which valine 66 is replaced by lysine, has been solved at 1.97 A resolution. Unlike lysine residues in previously reported protein structures, this residue appears to bury its side-chain in the hydrophobic core without salt brid...
Topics
- Computer Simulation
- Hydrogen-Ion Concentration
- Lysine
- Micrococcal Nuclease
- Mutation
- Protein Conformation
- Regression Analysis
- Thermodynamics
- Valine
- X-Ray Diffraction