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Article

Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1.

Journal of virology - 1 Aug 1993

Poon A P, Roizman B

Abstract excerpt

The UL15 gene of herpes simplex virus 1 consists of two exons and is highly conserved among the herpesviruses sequenced to date. Other than its homology to a phage protein involved in the packaging of DNA, nothing is known of its function. This report concerns the isolation of a temperature-sensitive mutant with a mutation mapping in the UL15 open reading frame. Cells infected with the parent, mutant, and rescued...

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Identifiers

PMID: 8331721
DOI: 10.1128/JVI.67.8.4497-4503.1993
PMCID: PMC237833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1.PMID 8331721Read ↗

Genetic analysis of the UL 15 gene locus for the putative terminase of herpes simplex virus type 1.Semantic proximity Read ↗

The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA.Semantic proximity Read ↗

The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centresSemantic proximity Read ↗

Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins.Semantic proximity Read ↗

Interaction of the herpes simplex virus type 1 packaging protein UL15 with full-length and deleted forms of the UL28 proteinSemantic proximity Read ↗

The U(L)15 gene of herpes simplex virus type 1 contains within its second exon a novel open reading frame that is translated in frame with the U(L)15 gene product.Semantic proximity Read ↗

The UL25 gene product of herpes simplex virus type 1 is involved in uncoating of the viral genome.Semantic proximity Read ↗

Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28.Semantic proximity Read ↗

Packaging of genomic and amplicon DNA by the herpes simplex virus type 1 UL25-null mutant KUL25NS.Semantic proximity Read ↗

Comparative Analysis of <i>UL16</i> Mutants Derived from Multiple Strains of HSV-2 and HSV-1 Reveals Species-Specific Requirements for the UL16 ProteinSemantic proximity Read ↗

Comparative Analysis of UL16 Mutants Derived from Multiple Strains of Herpes Simplex Virus 2 (HSV-2) and HSV-1 Reveals Species-Specific Requirements for the UL16 Protein.Semantic proximity Read ↗

The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 proteinSemantic proximity Read ↗

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