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Article

The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA.

Journal of virology - 1 Dec 1994

Baines J D, Poon A P, Rovnak J, Roizman B

Abstract excerpt

Previous studies have shown that a ts mutant [herpes simplex virus 1 (mP)ts66.4] in the UL15 gene fails to package viral DNA into capsids (A. P. W. Poon and B. Roizman, J. Virol. 67:4497-4503, 1993) and that although the intron separating the first and second exons of the UL15 gene contains UL16...

Topics

Animals
Base Sequence
Cell Line
Cells, Cultured
Chlorocebus aethiops
DNA Probes
DNA, Viral
Genes, Viral
Genome, Viral
Genotype
Herpesvirus 1, Human
Humans
Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Oligodeoxyribonucleotides

Rabbits

Skin

Thymidine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 7966602
DOI: 10.1128/JVI.68.12.8118-8124.1994
PMCID: PMC237276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7966602-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA.PMID 7966602Read ↗

Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins.Semantic proximity Read ↗

Genetic analysis of the UL 15 gene locus for the putative terminase of herpes simplex virus type 1.Semantic proximity Read ↗

The U(L)15 gene of herpes simplex virus type 1 contains within its second exon a novel open reading frame that is translated in frame with the U(L)15 gene product.Semantic proximity Read ↗

The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centresSemantic proximity Read ↗

Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1.Semantic proximity Read ↗

Interaction of the herpes simplex virus type 1 packaging protein UL15 with full-length and deleted forms of the UL28 proteinSemantic proximity Read ↗

Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28.Semantic proximity Read ↗

The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 proteinSemantic proximity Read ↗

Linker insertion mutations in the herpes simplex virus type 1 UL28 gene: effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation.Semantic proximity Read ↗

Herpes simplex virus DNA cleavage and packaging proteins associate with the procapsid prior to its maturation.Semantic proximity Read ↗

Isolation and characterization of the herpes simplex virus 1 terminase complex.Semantic proximity Read ↗

Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein.Semantic proximity Read ↗

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