A procedure for combining two-point lod scores into a summary multipoint map.

Abstract excerpt

Multipoint linkage analysis can be extremely demanding in terms of computer time and memory, and these requirements rise exponentially with the number of markers used. A method is described for producing a rapid approximation to a multipoint analysis from the supplied results of two-point analyses with each marker. The method depends on regarding the lod scores as if they were obtained from a number of...

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