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Article

Putative F-G loop is involved in association with the membrane in P450scc (P450 11A1).

Molecular and cellular endocrinology - 27 Feb 2004

Pikuleva Irina A

Abstract excerpt

Cytochrome P450scc (P450 11A1) catalyzes the conversion of cholesterol to pregnenolone, the first step in overall steroid hormone biosynthesis in steroidogenic tissues. On the basis of alignment with structurally characterized cytochromes P450 (P450s), we have identified the putative F-G loop of P450 11A1 and mutated amino acid residues in this region. Wild type and mutant P450s 11A1 were expressed in E. coli and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15026189
DOI: 10.1016/j.mce.2003.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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