Article
On the effect of cholesterol on the fate of CYP11A1 imported into yeast mitochondria in vivo.
Biochemistry. Biokhimiia - 1 Oct 2000
Kovaleva I E, Grivennikov S I, Luzikov V N
Abstract excerpt
It has earlier been shown that CYP11A1 (cytochrome P450scc precursor), synthesized in yeast cells, is imported into yeast mitochondria. However, in large part the foreign protein undergoes degradation or aggregates. In this work, we tried to prevent aggregation of CYP11A1 and stimulate its insertion into the mitochondrial inner membrane by substituting cholesterol (a substrate for cytochrome P450scc) for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.