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Article

Pathogenic autoantibodies in the NZB mouse are specific for erythrocyte Band 3 protein

1 Jul 1993

Abstract excerpt

NZB mice spontaneously develop autoimmune hemolytic anemia (AIHA). The red blood cell (RBC) autoantigen bound by pathogenic IgG autoantibodies, previously designated "X", was identified by immunoprecipitation. Autoantibody eluted from the RBC of AIHA-positive NZB mice precipitated a 105-kDa antigen that was identical in apparent molecular mass to Band 3, the RBC anion channel protein. Furthermore, the...

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PMID: 8325343
DOI: 10.1002/eji.1830230750

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