Article
Changes in the blood group Wright antigens are associated with a mutation at amino acid 658 in human erythrocyte band 3: a site of interaction between band 3 and glycophorin A under certain conditions.
Blood - 15 Jan 1995
Bruce L J, Ring S M, Anstee D J, Reid M E, Wilkinson S, Tanner M J
Abstract excerpt
The Wright (Wr) blood group antigens, Wra and Wrb, have been suggested to be determined by alleles of the same gene. The Wrb antigen appears to involve both red blood cell (RBC) band 3 and glycophorin A (GPA). We have examined the cDNA sequences of the band 3 and GPA of one of the two known Wr(a+b-) individuals. We show that this individual is homozygous for the mutation Glu658-->Lys in band 3, but has normal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.