Common model of normal cell differentiation and oncogenesis based on the mutation--recombination effects of transposable genetic elements and of provirus states.

Abstract excerpt

Cell differentiation would result from a sequence of mutation--recombination events that occur in quantal cell cycles, initiating cell lineages. The cytogenomic proviruses--transposable elements ensemble would represent the mutation--recombination equipment of differentiation. Carcinogenesis, as a consequence of multicausally induced mutation--recombination events, would likewise occur in a particular quantal...

Topics

• Animals
• Biological Evolution
• Cell Cycle
• Cell Differentiation
• Cell Transformation, Neoplastic
• DNA Repair
• DNA Transposable Elements
• Genes, Viral
• Humans
• Models, Biological
• Mutation