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Article

The p53-mdm-2 autoregulatory feedback loop.

Genes & development - 1 Jul 1993

Wu X, Bayle J H, Olson D, Levine A J

Abstract excerpt

The p53 protein can bind to a set of specific DNA sequences, and this may activate the transcription of genes adjacent to these DNA elements. The mdm-2 gene is shown here to contain a p53 DNA-binding site and a genetically responsive element such that expression of the mdm-2 gene can be regulated by the level of wild-type p53 protein. The mdm-2 protein, in turn, can complex with p53 and decrease its ability to...

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Identifiers

PMID: 8319905
DOI: 10.1101/gad.7.7a.1126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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