Aberrant p53 protein expression in cervical intra-epithelial neoplasia.

doi:10.1111/j.1365-2559.1993.tb00497.x

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Article

Aberrant p53 protein expression in cervical intra-epithelial neoplasia.

Histopathology - 1 Nov 1993

Pöllänen R, Soini Y, Vähäkangas K, Pääkkö P, Lehto V P

Abstract excerpt

We investigated aberrant p53 expression in 81 cases of cervical intra-epithelial neoplasias (CIN) using a polyclonal antibody CM-1. The presence of human papillomavirus (HPV) DNA was evaluated by in situ and dot blot hybridization. Significant (more than 1% of cells positive) p53 positivity was f...

Topics

DNA, Viral
Female
Gene Expression
Genes, p53
Humans
Mutation
Papillomaviridae
Precancerous Conditions
Tumor Suppressor Protein p53
Uterine Cervical Neoplasms
Uterine Cervical Dysplasia

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