Article
Lack of evidence for maternal effect in familial Alzheimer's disease.
Genetic epidemiology - 1 Jan 1993
Payami H, Hoffbuhr K
Abstract excerpt
Mitochondrial defects may be involved in Alzheimer's disease (AD) by lowering the oxidative phosphorylation efficiency at an earlier age. To investigate the possible contribution of an inherited mitochondrial DNA defect to familial AD (FAD), we examined the Genetic Analysis Workshop (GAW) data for evidence of maternal transmission and the effect on the age of onset. We found no evidence in support of inherited...
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