Article
Hematopoietic repopulation of adult mice with beta-thalassemia.
Blood - 1 Feb 1994
Barker J E, Compton S T
Abstract excerpt
Deletion of the murine beta-major globin gene on chromosome 7 causes a severe, hypochromic anemia in homozygous mice. We show that over 50% of the homozygous mice die either in utero or at birth. Mice heterozygous for the deletion have a slightly increased percentage of reticulocytes when compare...
Topics
- Animals
- Bone Marrow Transplantation
- Erythrocyte Count
- Female
- Hematopoiesis
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mutation
- Radiation Dosage
- beta-Thalassemia