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Article

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

BioMed research international - 1 Jan 2015

Breveglieri Giulia, Mancini Irene, Bianchi Nicoletta, Lampronti Ilaria, Salvatori Francesca, Fabbri Enrica, Zuccato Cristina, Cosenza Lucia C, Montagner Giulia, Borgatti Monica, Altruda Fiorella, Fagoonee Sharmila, Carandina Gianni, Rubini Michele, Aiello Vincenzo, Breda Laura, Rivella Stefano, Gambari Roberto, Finotti Alessia

Abstract excerpt

Mouse models that carry mutations causing thalassemia represent a suitable tool to test in vivo new mutation-specific therapeutic approaches. Transgenic mice carrying the β-globin IVSI-6 mutation (the most frequent in Middle-Eastern regions and recurrent in Italy and Greece) are, at present, not available. We report the production and characterization of a transgenic mouse line (TG-β-IVSI-6) carrying the IVSI-6...

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Identifiers

PMID: 26097845
DOI: 10.1155/2015/687635
PMCID: PMC4434229

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Source receipt: pubmed, retrieved 7 Sept 2026.

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