Article
Retrovirus-mediated transfer of the erythropoietin gene in hematopoietic cells improves the erythrocyte phenotype in murine beta-thalassemia.
Blood - 1 Aug 1994
Villeval J L, Rouyer-Fessard P, Blumenfeld N, Henri A, Vainchenker W, Beuzard Y
Abstract excerpt
Repeated injections of large doses of erythropoietin (Epo) have been shown to be of benefit in the treatment of murine and human beta-thalassemia. To determine whether Epo gene therapy could replace this treatment for long-term periods, lethally irradiated beta-thalassemic (Hbbd3th haplotype) and...
Topics
- Animals
- Bone Marrow
- DNA, Viral
- Erythropoietin
- Female
- Gene Transfer Techniques
- Genetic Therapy
- Genetic Vectors
- Hematocrit
- Hematopoiesis
- Hematopoietic Stem Cells
- Mice
- Mice, Inbred DBA
- Phenotype
- Proviruses
- Retroviridae
- Spleen
- beta-Thalassemia