Article
Fetal hematopoietic stem cell transplantation into beta-thalassemic mice.
Journal of pediatric surgery - 1 Oct 1993
Bethel C A, Muragesh D, Harrison M R, Mohandas N, Rubin E R
Abstract excerpt
The transplantation of fetal-derived hematopoietic stem cells (HSCs) may potentially be used to treat hemoglobinopathies, immunodeficiencies, and storage diseases. The levels of donor cell engraftment needed to reconstitute the recipient's hematopoietic system are disease-dependent and remain unknown for most deficiencies. We have explored the application of fetal hematopoietic stem cell transplants for the...
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