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Article

ELISA-Based Detection System for Protein S K196E Mutation, a Genetic Risk Factor for Venous Thromboembolism.

PloS one - 1 Jan 2015

Maruyama Keiko, Akiyama Masashi, Kokame Koichi, Sekiya Akiko, Morishita Eriko, Miyata Toshiyuki

Abstract excerpt

Protein S (PS) acts as a cofactor for activated protein C in the plasma anticoagulant system. PS Lys196-to-Glu (K196E) mutation is a genetic risk factor for venous thromboembolism in Japanese individuals. Because of the substantial overlap in PS anticoagulant activity between KK (wild-type) and KE (heterozygous) genotypes, it is difficult to identify PS K196E carriers by measuring PS activity. Here, we generated...

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Identifiers

PMID: 26186226
DOI: 10.1371/journal.pone.0133196
PMCID: PMC4505939

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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