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Article

Detection of nondisjunction and recombination in meiotic and postmeiotic cells from XYSxr [XY,Tp(Y)1Ct] mice using multicolor fluorescence in situ hybridization.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 1994

Ashley T, Ried T, Ward D C

Abstract excerpt

Current meiotic dogma holds that synapsis is required for recombination and that recombination is required for proper disjunction. The mouse chromosome aberration XYSxr [sex reversal; redesignated XY,Tp(Y)1Ct] appears to challenge this assumption, for although chromosomes X and Y often fail to synapse and recombine, there is no dramatic increase in aneuploid progeny. An explanation of this conundrum might be that...

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Identifiers

PMID: 8290558
DOI: 10.1073/pnas.91.2.524
PMCID: PMC42981

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