Aneuploidy in late-step spermatids of mice detected by two-chromosome fluorescence in situ hybridization.

doi:10.1002/mrd.1080400216

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Article

Aneuploidy in late-step spermatids of mice detected by two-chromosome fluorescence in situ hybridization.

Molecular reproduction and development - 1 Feb 1995

Wyrobek A, Lowe X, Pinkel D, Bishop J

Abstract excerpt

A multicolor procedure employing fluorescence in situ hybridization is described for detecting chromosomal domains and germinal aneuploidy in late-step spermatids in mice using DNA probes specific for repetitive sequences near the centromeres of chromosomes 8 and X. These probes were nick-translated with biotin- or digoxigenin-labeled nucleotides, and were detected with FITC or rhodamine. Probe and hybridization...

Topics

Aneuploidy
Animals
Bone Marrow Cells
Centromere
Chromosomes
DNA Probes
Haploidy
Humans
In Situ Hybridization, Fluorescence
Lymphocytes
Male
Meiosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metaphase

Mice

Mice, Inbred C3H

Mice, Inbred C57BL

Organ Specificity

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7766420
DOI: 10.1002/mrd.1080400216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7766420-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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