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Article

Importance of amino acid 101 within capsid protein VP1 for modulation of Theiler's virus-induced disease.

Journal of virology - 1 Feb 1994

Wada Y, Pierce M L, Fujinami R S

Abstract excerpt

We constructed a Theiler's virus mutant designated DA3304, in which the amino acid at position 101 of VP1 was changed from a threonine to an alanine. Because of this single amino acid change, DA3304 could still produce a biphasic central nervous system disease similar to that produced by the wild-type DA virus. However, DA3304 was significantly attenuated in both the acute and the chronic phases and induced...

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Identifiers

PMID: 8289355
DOI: 10.1128/JVI.68.2.1219-1223.1994
PMCID: PMC236565

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