Importance of amino acid 101 within capsid protein VP1 for modulation of Theiler's virus-induced disease.

Abstract excerpt

We constructed a Theiler's virus mutant designated DA3304, in which the amino acid at position 101 of VP1 was changed from a threonine to an alanine. Because of this single amino acid change, DA3304 could still produce a biphasic central nervous system disease similar to that produced by the wild...

Topics

• Animals
• Base Sequence
• Capsid
• Capsid Proteins
• Cells, Cultured
• Central Nervous System
• Female
• Mice
• Mice, Inbred Strains
• Molecular Sequence Data
• Mutation
• Poliomyelitis
• Theilovirus