Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase.

Virology - 5 Jan 2010

Kung Yen-Hua, Huang Sheng-Wen, Kuo Pin-Hwa, Kiang David, Ho Mei-Shang, Liu Ching-Chung, Yu Chun-Keung, Su Ih-Jen, Wang Jen-Ren

Abstract excerpt

In 1998, an enterovirus 71 (EV71) epidemic in Taiwan resulted in 78 deaths; however, the molecular basis of EV71 pathogenicity remains poorly understood. Comparison of the deduced amino acid sequences in 3D polymerases of EV71clinical isolates showed the T251V or T251I substitution from 1986 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed RNA Polymerases
Share to Enterovirus A, Human
Share to Hand, Foot and Mouth Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Viral

Share to Structure-Activity Relationship

Share to Temperature

Share to Virulence

Source

Identifiers

PMID: 19906393
DOI: 10.1016/j.virol.2009.10.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19906393-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase.PMID 19906393Read ↗

Contribution of 3CD Region to the Virulence of Enterovirus 71.Semantic proximity Read ↗

Phenotypic and genotypic characteristics of novel mouse cell line (NIH/3T3)-adapted human enterovirus 71 strains (EV71:TLLm and EV71:TLLmv).Semantic proximity Read ↗

Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry.Semantic proximity Read ↗

Contemporary Enterovirus D68 strains show enhanced replication and translation at 37°CSemantic proximity Read ↗

A Single Nucleotide in Stem Loop II of 5′-Untranslated Region Contributes to Virulence of Enterovirus 71 in MiceSemantic proximity Read ↗

Molecular Analysis of Virulent Determinants of Enterovirus 71Semantic proximity Read ↗

Genetic characterization of enterovirus 71 isolated from patients with severe disease by comparative analysis of complete genomesSemantic proximity Read ↗

Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement.Semantic proximity Read ↗

Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection.Semantic proximity Read ↗

A Mouse-Adapted Enterovirus 71 Strain Causes Neurological Disease in Mice after Oral InfectionSemantic proximity Read ↗

A fatal case of enterovirus 71 infection with a single nucleotide variation in domain V of the 5' untranslated region.Semantic proximity Read ↗

A Single Mutation in the VP1 of Enterovirus 71 Is Responsible for Increased Virulence and Neurotropism in Adult Interferon-Deficient MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.