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Article

DNA helical instability facilitates initiation at the SV40 replication origin.

Journal of molecular biology - 14 Jan 1994

Lin S, Kowalski D

Abstract excerpt

Previous analysis of mutations in bacterial and yeast replication origins has identified a genetic component, termed a DNA unwinding element (DUE), whose intrinsic helical instability is essential for origin function. For the SV40 replication origin, we show here that the early palindrome (EP) and A + T-rich (AT) domains both exhibit helical instability, despite their dissimilar A + T compositions. To test the...

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Source

Identifiers

PMID: 8289278
DOI: 10.1006/jmbi.1994.1009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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