Article
Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome.
The Journal of investigative dermatology - 1 Jan 1994
Rünger T M, Bauer C, Dekant B, Möller K, Sobotta P, Czerny C, Poot M, Martin G M
Abstract excerpt
Werner Syndrome is a rare autosomal recessive disorder characterized by an increased cancer risk and by symptoms suggestive of premature aging. Cells from these patients demonstrate a typical pattern of chromosomal instability and a spontaneous hypermutability with a high rate of unusually large...
Topics
- Cell Line
- DNA
- DNA, Bacterial
- Gene Deletion
- Humans
- Lymphocytes
- Mutation
- Plasmids
- Transfection
- Werner Syndrome