Article
Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome.
The Journal of investigative dermatology - 1 Jan 1994
Rünger T M, Bauer C, Dekant B, Möller K, Sobotta P, Czerny C, Poot M, Martin G M
Abstract excerpt
Werner Syndrome is a rare autosomal recessive disorder characterized by an increased cancer risk and by symptoms suggestive of premature aging. Cells from these patients demonstrate a typical pattern of chromosomal instability and a spontaneous hypermutability with a high rate of unusually large deletions. We have studied the in vivo DNA ligation in three lymphoblast cell lines from Werner syndrome patients and...
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