Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic correction of a human cell line (46BR) with aberrant DNA ligase I activity.

Mutation research - 1 Jun 1993

Somia N V, Jessop J K, Melton D W

Abstract excerpt

Ligation of DNA after replication and repair is a prerequisite for the preservation of DNA and chromosome structure and function. Biochemical studies with Bloom's syndrome cells have revealed an abnormal DNA ligase I activity. However, genetic analysis has not revealed any differences in transcript levels or in the cDNA sequences of DNA ligase I between Bloom's syndrome and normal cells. Another human cell line,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Transformed
Share to DNA Repair
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Mutation

Share to Phenotype

Share to Plasmids

Share to Transfection

Source

Identifiers

PMID: 7683758
DOI: 10.1016/0921-8777(93)90057-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic correction of a human cell line (46BR) with aberrant DNA ligase I activity.PMID 7683758Read ↗

Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I.Semantic proximity Read ↗

Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.Semantic proximity Read ↗

DNA ligase I deficiency in Bloom's syndrome.Semantic proximity Read ↗

Altered DNA ligase I activity in Bloom's syndrome cells.Semantic proximity Read ↗

Altered DNA ligase activity in human diseaseSemantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Ligase IV syndrome.Semantic proximity Read ↗

A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks.Semantic proximity Read ↗

Specific function of DNA ligase I in simian virus 40 DNA replication by human cell-free extracts is mediated by the amino-terminal non-catalytic domain.Semantic proximity Read ↗

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.Semantic proximity Read ↗

Identification of a novel motif in DNA ligases exemplified by DNA ligase IV.Semantic proximity Read ↗

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.