Phenotypic correction of a human cell line (46BR) with aberrant DNA ligase I activity.

doi:10.1016/0921-8777(93)90057-n

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Article

Phenotypic correction of a human cell line (46BR) with aberrant DNA ligase I activity.

Mutation research - 1 Jun 1993

Somia N V, Jessop J K, Melton D W

Abstract excerpt

Ligation of DNA after replication and repair is a prerequisite for the preservation of DNA and chromosome structure and function. Biochemical studies with Bloom's syndrome cells have revealed an abnormal DNA ligase I activity. However, genetic analysis has not revealed any differences in transcript levels or in the cDNA sequences of DNA ligase I between Bloom's syndrome and normal cells. Another human cell line,...

Topics

Benzamides
Bloom Syndrome
Cell Line, Transformed
DNA Ligase ATP
DNA Ligases
DNA Repair
Ethyl Methanesulfonate
Fibroblasts
Humans
Immunoblotting
Kanamycin Kinase
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Mutation

Phenotype

Phosphotransferases

Plasmids

Transfection

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Identifiers

PMID: 7683758
DOI: 10.1016/0921-8777(93)90057-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7683758-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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