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Article

Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations.

Oncogene - 6 Jun 1996

Liu P K, Kraus E, Wu T A, Strong L C, Tainsky M A

Abstract excerpt

Germline p53 mutations are frequently observed in the normal DNA of cancer-prone patients with Li-Fraumeni syndrome (LFS). Fibroblasts from LFS patients develop chromosomal aberrations, loss of cell cycle control, and spontaneous immortalization. We transfected four different mutant p53 genes into human skin fibroblasts from normal donors with two copies of wild-type p53 (p53(wt/wt)). Each mutant p53...

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Identifiers

PMID: 8649766
PMCID: PMC2719722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations.PMID 8649766Read ↗

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