Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndromea

1 Sept 1993

Abstract excerpt

A four- to fivefold overexpression of the gene for the Alzheimer beta/A4 amyloid precursor protein (APP) in individuals with Down's Syndrome (DS) appears to be responsible for the fifty year earlier onset of Alzheimer's disease (AD) pathology in DS compared to the normal population. It is therefore likely that a deregulated overexpression of the APP gene is a risk factor for the beta/A4 amyloid formation. To test...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Nuclear Receptors and Signaling
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8239320
DOI: 10.1111/j.1749-6632.1993.tb23035.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's SyndromeaPMID 8239320Read ↗

Alzheimer's Disease in the Down Syndrome: An Overview of Genetics and Molecular AspectsSemantic proximity Read ↗

Common genetic signatures of Alzheimer’s disease in Down SyndromeSemantic proximity Read ↗

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived NeuronsSemantic proximity Read ↗

Amyloid-β protein precursor gene expression in alzheimer's disease and other conditions.Semantic proximity Read ↗

Impact of increased APP gene dose in Down syndrome and the Dp16 mouse modelSemantic proximity Read ↗

Down's Syndrome: Up‐Regulation of β‐Amyloid Protein Precursor and τ mRNAs and Their Defective CoordinationSemantic proximity Read ↗

The human β-amyloid precursor protein: biomolecular and epigenetic aspectsSemantic proximity Read ↗

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.Semantic proximity Read ↗

Beta-amyloid, oxidative stress and down syndrome.Semantic proximity Read ↗

Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologySemantic proximity Read ↗

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down SyndromeSemantic proximity Read ↗

Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.