Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor.

Article

Elimination of the O-linked glycosylation site at Thr 104 results in the generation of a soluble human-transferrin receptor.

Blood - 15 Jan 1994

Rutledge E A, Root B J, Lucas J J, Enns C A

Abstract excerpt

The transferrin receptor (TfR) is the plasma membrane protein responsible for the binding and internalization of the major iron-transport protein, transferrin. The function of the single O-linked oligosaccharide near the transmembrane domain of the TfR at amino acid Thr 104 is unknown. To elucida...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cricetinae
Erythropoiesis
Glycosylation
Humans
Molecular Sequence Data
Mutation
Receptors, Transferrin
Threonine

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