Article
Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
Genomics - 15 Jul 1994
McGregor L M, Baylin S B, Griffin C A, Hawkins A L, Nelkin B D
Abstract excerpt
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system. We have cloned and sequenced the human trkC cDNA and found that the predicted amino acid sequence is 97 to 98% homologous to the rat and po...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 15
- Cloning, Molecular
- DNA, Complementary
- Genetic Variation
- Humans
- Hybrid Cells
- Molecular Sequence Data
- Polymerase Chain Reaction
- RNA Splicing
- Rats
- Receptor Protein-Tyrosine Kinases
- Receptor, trkC
- Receptors, Nerve Growth Factor
- Rodentia
