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Article

In vivo selection of conditional-lethal mutations in the gene encoding elongation factor G of Escherichia coli.

Journal of bacteriology - 1 Jan 1994

Hou Y, Lin Y P, Sharer J D, March P E

Abstract excerpt

The ribosome translocation step that occurs during protein synthesis is a highly conserved, essential activity of all cells. The precise movement of one codon that occurs following peptide bond formation is regulated by elongation factor G (EF-G) in eubacteria or elongation factor 2 (EF-2) in eukaryotes. To begin to understand molecular interactions that regulate this process, a genetic selection was developed...

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Identifiers

PMID: 8282687
DOI: 10.1128/jb.176.1.123-129.1994
PMCID: PMC205022

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Source receipt: pubmed, retrieved 7 Sept 2026.

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