Insertional mutation of the hairless locus on mouse chromosome 14.

doi:10.1007/BF00360900

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Article

Insertional mutation of the hairless locus on mouse chromosome 14.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Nov 1993

Jones J M, Elder J T, Simin K, Keller S A, Meisler M H

Abstract excerpt

Crosses between heterozygous transgenic mice from line 5053 produced offspring with progressive irreversible hair loss beginning at day 19. With increasing age, the skin of these animals became thicker and plicated in appearance. Histological analysis revealed the complete absence of normal hair...

Topics

Alleles
Alopecia
Animals
Crosses, Genetic
Genes, Recessive
Genetic Complementation Test
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Phenotype
Polymerase Chain Reaction
Skin

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