Toxicity of phorbol esters for human epithelial cells expressing a mutant ras oncogene.

doi:10.1002/mc.2940080411

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Article

Toxicity of phorbol esters for human epithelial cells expressing a mutant ras oncogene.

Molecular carcinogenesis - 1 Jan 1993

Dawson T, Bond J, Eccles N, Wynford-Thomas D

Abstract excerpt

Phorbol esters and related compounds provide a promising source of potential anticancer agents. The mechanism of their toxicity, however, is unclear, and interpretation has been complicated by the conflicting responses exhibited by different transformed cell lines. Previously we showed that in pr...

Topics

Antineoplastic Agents
Bryostatins
Cell Division
Cell Line
DNA
Epithelial Cells
Epithelium
Gene Expression Regulation
Genes, ras
Humans
Lactones
Macrolides
Models, Biological
Mutation
Phorbol 12,13-Dibutyrate
Phorbol Esters
Proto-Oncogene Proteins p21(ras)
Structure-Activity Relationship

Source

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Identifiers

PMID: 8280376
DOI: 10.1002/mc.2940080411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8280376-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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