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Article

Effect of single base substitutions at glycine-870 codon of gramicidin S synthetase 2 gene on proline activation.

Journal of biochemistry - 1 Oct 1993

Tokita K, Hori K, Kurotsu T, Kanda M, Saito Y

Abstract excerpt

The mutant gene coding for a proline-activating domain (grs2-pro) was cloned and sequenced from Bacillus brevis Nagano, BII-3 strain, which produces gramicidin S synthetase 2 defective in proline-activation. By comparison of the nucleotide sequence with the wild-type sequence, a single point mutation was found at the 2609th guanine, which was replaced with adenine, resulting in the change of the 870th glycine to...

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PMID: 8276762
DOI: 10.1093/oxfordjournals.jbchem.a124210

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