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Article

Human papillomavirus-immortalized keratinocytes are resistant to the effects of retinoic acid on terminal differentiation.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1993

Merrick D T, Gown A M, Halbert C L, Blanton R A, McDougall J K

Abstract excerpt

In order to study how human papillomaviruses (HPVs) can alter normal epithelial cell differentiation, we looked at the response to retinoic acid (RA) of HPV-immortalized keratinocytes grown on organotypic cultures. Ten- to 30-fold higher concentrations of RA were required to block terminal differentiation in these cultures when compared to organotypic cultures of control cells. This resistance to RA was...

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PMID: 8274452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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