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Article

Immortalization by human papillomavirus type 16 alters retinoid regulation of human ectocervical epithelial cell differentiation.

Cancer research - 1 Aug 1991

Agarwal C, Rorke E A, Irwin J C, Eckert R L

Abstract excerpt

Human cervical cells are a primary site of papillomavirus infection and 90% of all cervical tumors are positive for human papillomavirus (HPV) DNA. Over one-half million cases of HPV-associated cervical, vulvar, and penile cancers are reported per year. Yet, in spite of the magnitude of this problem, the effects of HPV infection on cervical cell growth and differentiation are not well characterized. To study...

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PMID: 1713124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Immortalization by human papillomavirus type 16 alters retinoid regulation of human ectocervical epithelial cell differentiation.PMID 1713124Read ↗

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Human papillomavirus-immortalized keratinocytes are resistant to the effects of retinoic acid on terminal differentiation.Semantic proximity Read ↗

Effect of Retinoids on Hyperproliferation-Associated Keratins K6 and K16 in Cultured Human Keratinocytes: A Quantitative AnalysisSemantic proximity Read ↗

The E5 Gene of HPV-16 Enhances Keratinocyte Immortalization by Full-Length DNASemantic proximity Read ↗

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Semantic proximity Read ↗

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytesSemantic proximity Read ↗

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18Semantic proximity Read ↗

Cell-Restricted Immortalization by Human Papillomavirus Correlates with Telomerase Activation and Engagement of the hTERT Promoter by MycSemantic proximity Read ↗

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