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Article

Chloride conductance in mouse muscle is subject to post-transcriptional compensation of the functional Cl- channel 1 gene dosage.

The Journal of physiology - 1 Oct 1997

Chen M F, Niggeweg R, Iaizzo P A, Lehmann-Horn F, Jockusch H

Abstract excerpt

1. In mature mammalian muscle, the muscular chloride channel ClC-1 contributes about 75% of the sarcolemmal resting conductance (Gm). In mice carrying two defective alleles of the corresponding Clc1 gene, chloride conductance (GCl) is reduced to less than 10% of that of wild-type, and this causes hyperexcitability, the salient feature of the disease myotonia. Potassium conductance (GK) values in myotonic mouse...

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Identifiers

PMID: 9350619
DOI: 10.1111/j.1469-7793.1997.075bf.x
PMCID: PMC1159937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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