Article
Chloride conductance in mouse muscle is subject to post-transcriptional compensation of the functional Cl- channel 1 gene dosage.
The Journal of physiology - 1 Oct 1997
Chen M F, Niggeweg R, Iaizzo P A, Lehmann-Horn F, Jockusch H
Abstract excerpt
1. In mature mammalian muscle, the muscular chloride channel ClC-1 contributes about 75% of the sarcolemmal resting conductance (Gm). In mice carrying two defective alleles of the corresponding Clc1 gene, chloride conductance (GCl) is reduced to less than 10% of that of wild-type, and this causes...
Topics
- Alleles
- Animals
- Chloride Channels
- Gene Dosage
- Genes
- Genotype
- Mice
- Muscle, Skeletal
- Mutation
- Myotonia
- Protein Processing, Post-Translational
- RNA, Messenger
- Sarcolemma