Article
Ectopic expression of tmie transgene induces various recovery levels of behavior and hearing ability in the circling mouse.
Biochemical and biophysical research communications - 12 Sept 2008
Shin Mi Jung, Lee Jeong-Han, Yu Dong Hoon, Kim Bong Soo, Kim Hei Jung, Kim Sung Hyun, Kim Myoung Ok, Park Channy, Hyun Byung-Hwa, Lee Sanggyu, So Hong-Seob, Park Raekil, Ryoo Zae Young
Abstract excerpt
The circling (cir/cir) mouse is one of the murine models for human non-syndromic deafness DFNB6. The mice have abnormal circling behavior, suggesting a balanced disorder and profound deafness. The causative gene was transmembrane inner ear (tmie) gene of which the mutation is a 40-kb genomic deletion including tmie gene itself. In this study, tmie-overexpression trasngenic mice were established. Individuals with...
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