Article
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
Cell - 17 Dec 1993
Leach F S, Nicolaides N C, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomäki P, Sistonen P, Aaltonen L A, Nyström-Lahti M
Abstract excerpt
Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain alterations in microsatellite sequences (RER+ phenotype). We have used chromosome microdissection to obtain highly polymorphic markers from chromosome 2p16. These and other markers were ordered in a panel of somatic cell hybrids and used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.