Article
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
Cell - 17 Dec 1993
Leach F S, Nicolaides N C, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomäki P, Sistonen P, Aaltonen L A, Nyström-Lahti M
Abstract excerpt
Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain alterations in microsatellite sequences (RER+ phenotype). We have used chromosome microdissection to obtain highly poly...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- Cell Line
- Chromosome Banding
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- Colon
- Colonic Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Cricetinae
- DNA Primers
- DNA Repair
- DNA-Binding Proteins