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Article

Sequential topoisomerase targeting and analysis of mechanisms of resistance to topotecan in patients with acute myelogenous leukemia.

Anti-cancer drugs - 1 Apr 2008

Saraiya Biren, Gounder Murugesan, Dutta Jayeeta, Saleem Ahamed, Collazo Celeste, Zimmerman Luz, Nazar Ahamed, Gharibo Mecide, Schaar Dale, Lin Yong, Shih Weichung, Aisner Joseph, Strair Roger K, Rubin Eric H

Abstract excerpt

Resistance to topoisomerase I (TOP1)-targeting drugs such as topotecan often involves upregulation of topoisomerase II (TOP2), with accompanying increased sensitivity to TOP2-targeting drugs such as etoposide. This trial was designed to investigate sequential topoisomerase targeting in the treatment of patients with high-risk acute myelogenous leukemia. An initial cohort of patients received topotecan and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18454051
DOI: 10.1097/CAD.0b013e3282f5218b

Genes

TOP1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sequential topoisomerase targeting and analysis of mechanisms of resistance to topotecan in patients with acute myelogenous leukemia.PMID 18454051Read ↗

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