Article
An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.
Antiviral research - 1 Dec 2016
Bennett Ryan P, Stewart Ryan A, Hogan Priscilla A, Ptak Roger G, Mankowski Marie K, Hartman Tracy L, Buckheit Robert W, Snyder Beth A, Salter Jason D, Morales Guillermo A, Smith Harold C
Abstract excerpt
Camptothecin (CPT) is a natural product discovered to be active against various cancers through its ability to inhibit Topoisomerase I (TOP1). CPT analogs also have anti-HIV-1 (HIV) activity that was previously shown to be independent of TOP1 inhibition. We show that a cancer inactive CPT analog (O2-16) inhibits HIV infection by disrupting multimerization of the HIV protein Vif. Antiviral activity depended on the...
Topics
- APOBEC-3G Deaminase
- Camptothecin
- Cell Line
- DNA Topoisomerases, Type I
- Drug Resistance, Viral
- Genome, Viral
- HIV Infections
- HIV-1
- Humans
- Models, Molecular