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Article

Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme.

Journal of molecular biology - 14 Jun 1996

Baldwin E, Xu J, Hajiseyedjavadi O, Baase W A, Matthews B W

Abstract excerpt

Previous analysis of randomly generated multiple mutations within the core of bacteriophage T4 lysozyme suggested that the "large-to-small" substitution Leu121 to Ala (L121A) and the spatially adjacent "small-to-large" substitution Ala129 to Met (A129M) might be mutually compensating. To test this hypothesis, the individual variants L121A and A129M were generated, as well as the double "size-switch" mutant...

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Identifiers

PMID: 8676387
DOI: 10.1006/jmbi.1996.0338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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