Article
Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1991
Koo G C, Manyak C L, Dasch J, Ellingsworth L, Shultz L D
Abstract excerpt
Viable motheaten (mev) mice are homozygous for a recessive single gene mutation at chromosome 6. These mice develop numerous inflammatory and arthritic syndromes and exhibit abnormal B cell functions as well as lower T and NK cell activity. In this study, the differentiation of NK cells in mev mi...
Topics
- Animals
- Arthritis
- Autoimmune Diseases
- Bone Marrow Transplantation
- Cell Differentiation
- Hematopoietic Stem Cells
- Interferons
- Interleukin-2
- Killer Cells, Natural
- Mice
- Mice, Mutant Strains
- Phenotype
- Transforming Growth Factor beta